Mitochondrial system is totally shut down no O2 at the end of the electron transport system — can only get 2 ATP with anaerobic glycolysis. Good news — get 2 ATP Bad news — build up of lactic acid in the cell and outside the cell increased anion-gap metabolic acidosis with tissue hypoxia due to lactic acidosis from anaerobic glycolysis.
Therefore, buildup of lactic acid within the cell will lead to Coagulation necrosis. With no ATP, Na into the cell and it brings H20, which leads to cellular swelling which is reversible. Alright, now in this part of the article, you will be able to access the free Goljan USMLE Step 1 Audio Lectures using our direct links mentioned at the end of this article.
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